LATEST STUDY LED BY ZOE REVEALS WHY SOME OF US ARE HUNGRY ALL THE TIME ARE YOU A ‘BIG DIPPER’ OR A ‘LITTLE DIPPER’?

New results from PREDICT, the largest ongoing nutritional research program in the world that looks at responses to food in real life settings, show that people who experience big dips in blood sugar levels, several hours after eating, end up feeling hungrier and consuming hundreds more calories during the day than others.

Published today in Nature Metabolism, the research team at health science company ZOE (composed of scientists from Harvard Medical School, Harvard T.H. Chan School of Public Health, Massachusetts General Hospital, the University of Nottingham, King’s College London, Leeds University, and Lund University in Sweden) found why some people struggle to lose weight, even on calorie-controlled diets, and highlight the importance of understanding personal metabolism when it comes to diet and health.

The scoop on blood sugar dipping:

• More than 1,000 people took part in the study, which gathered detailed data about blood sugar responses and hunger after eating standardized and free-choice meals over two weeks.
• Researchers found big variations between individuals in how their blood sugar levels respond to various foods.
• People whose blood sugar levels dip significantly 2-4 hours after eating (‘big dippers’) are more likely to feel hungry sooner and consume an average of around 300 more calories over the course of the day than people with the smallest dips (‘little dippers’).
• Whether you’re a big or little dipper is likely to be a combination of your unique biology, meal choices and activity levels.
• Previous studies have only looked at how blood sugar rises and falls in the first two hours after eating affect hunger (blood sugar peaks), not the dips afterwards, so diet advice focused only on peaks won’t help to control your appetite.
• Understanding your personal metabolism and choosing foods that reduce the likelihood of having big dips could help to control hunger and body weight in the long term.



In the study, “Postprandial glycemic dips predict appetite and energy intake in healthy individuals,” the research team collected detailed data about blood sugar responses and other markers of health from 1,070 people after eating standardized breakfasts and freely chosen meals over a two week period, adding up to more than 8,000 breakfasts and 70,000 meals in total. The standard breakfasts were based on muffins containing the same amount of calories but varying in composition in terms of carbohydrates, protein, fat and fiber. Participants also carried out a fasting blood sugar response test (oral glucose tolerance test), to measure how well their body processes sugar.

Participants wore stick-on continuous glucose monitors (CGMs) to measure their blood sugar levels over the entire duration of the study, as well as a wearable device to monitor activity and sleep. The research team also asked people to record their levels of hunger and alertness using a phone app, along with exactly when and what they ate over the day.

Big dippers vs. little dippers

Previous studies looking at blood sugar after eating have focused on the way that levels rise and fall in the first two hours after a meal, known as a blood sugar peak. However, after analyzing the data, the PREDICT team noticed that some people experienced significant ‘sugar dips’ 2-4 hours after this initial peak, where their blood sugar levels fell rapidly below baseline before coming back up.



Latest study led by ZOE reveals why some of us are hungry all the time



Dr Sarah Berry from King’s College London, who was involved in the study, says, “It has long been suspected that blood sugar levels play an important role in controlling hunger, but the results from previous studies have been inconclusive. We’ve now shown that sugar dips are a better predictor of hunger and subsequent calorie intake than the initial blood sugar peak response after eating, changing how we think about the relationship between blood sugar levels and the food we eat.”

Big dippers had a 9% increase in hunger, and waited around half an hour less, on average, before their next meal than little dippers, even though they ate exactly the same meals.

Big dippers also ate 75 more calories in the 3-4 hours after breakfast and around 312 calories more over the whole day than little dippers. This kind of pattern could potentially turn into 20 pounds of weight gain over a year.

Professor Ana Valdes from the School of Medicine at the University of Nottingham, who led the study team, acknowledges, “Many people struggle to lose weight and keep it off, and just a few hundred extra calories every day can add up to several pounds of weight gain over a year. Our discovery that the size of sugar dips after eating has such a big impact on hunger and appetite has great potential for helping people understand and control their weight and long-term health.”

What makes you a big dipper or a little dipper?

Comparing what happens when participants eat the same test meals revealed large variations in blood sugar responses between people. The researchers also found no correlation between age, bodyweight or BMI and being a big or little dipper, although males had slightly larger dips than females on average. This is in keeping with previous findings from PREDICT showing that even identical twins can have different responses to the same foods.

There was also some variability in the size of the dips experienced by each person in response to eating the same meals on different days, suggesting that whether you’re a dipper or not depends on individual differences in metabolism, as well as the day-to-day effects of meal choices and activity levels.

Lead author on the study, Patrick Wyatt from ZOE, notes, “This study shows how wearable technology can provide valuable insights to help people understand their unique biology and take control of their nutrition and health. By demonstrating the importance of sugar dips, our study paves the way for data-driven, personalized guidance for those seeking to manage their hunger and calorie intake in a way that works with rather than against their body.”

Choosing foods that work together with your unique biology could help people feel fuller for longer and eat less overall. To help improve the country’s overall public health and bring science to the everyday person, ZOE now offers an at-home test that measures whether you’re a big or little dipper and provides personalized advice on the best foods to eat to take back control of your health and weight.

Tim Spector, Professor of Genetic Epidemiology at King’s College London and scientific co-founder of ZOE, concludes, “Food is complex and humans are complicated, but our research is finally starting to open up the black box between diet and health. We’re excited to have been able to turn this cutting-edge science into an at-home nutrition and microbiome test so that everyone has the opportunity to discover their unique responses to food to best support their metabolism and gut health.”

Find out more about the ZOE at-home test and nutrition program at joinzoe.com.

Notes:

• Link to proof of paper in Nature Metabolism: Postprandial glycemic dips predict appetite and energy intake in healthy individuals
• Find out more about the ZOE at-home test and nutrition program at joinzoe.com