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Tiziana (NASDAQ: TLSA) Continues The Fight Against Multiple Sclerosis, Will Announce 6-Month Results For Its Novel Treatment Soon

Benzinga

By David Willey, Benzinga Tiziana Life Sciences (NASDAQ: TLSA), a clinical-stage biotechnology company focused on developing immunotherapies, will soon announce the 6-month results for patients with non-active Secondary Progressive Multiple Sclerosis (na-SPMS) receiving its novel intranasal treatment, foralumab. The company is conducting an expanded access program, where patients with non active secondary progressive multiple sclerosis (Na-SPMS) received foralumab, and a Positron Emission Tomography (PET) brain scan was taken for each patient at the 3-month mark. Tiziana declared that the findings were “extraordinary,” as the trial saw reduced microglia activity in five of the six patients with na-SPMS. This result indicates reduced neuroinflammation for these five patients and the possibility of an improvement in their condition. “To see a reduction in microglial activation in 5 out of 6 na-SPMS patients in only 3 months is extraordinary. This finding is even more remarkable because all of the 6 expanded access patients’ na-SPMS had clinically regressed on ocrelizumab treatment,” said Howard L. Weiner, M.D, chairman of Tiziana's Scientific Advisory Board. He continued, “I am excited to follow this program to see if the improvement in the 3-month PET scans will translate to clinical improvement in the coming months.” Now Tiziana is approaching the 6-month mark for its patients in the program and will be publishing the results for these patients. The company will be hoping that the positive results it saw at the 3-month mark will be replicated. It also anticipates progressing clinical development for foralumab by starting a phase 2 trial in Q3 of 2023. Foralumab Could Decrease NeuroInflammation These results are expected even as a recent study linked MS to a greater risk of Alzheimer's and dementia. Tiziana is tackling MS, Alzheimer’s and other neuroinflammatory diseases with foralumab, which reduces neuroinflammation caused by microglia activated by amyloid plaque buildup. By binding to regulatory T-cells, foralumab is able to cross the blood-brain barrier, decrease microglia activation and reduce neuroinflammation. Anti-CD3 monoclonal antibodies (mAb) are a class of therapy that reduces inflammation, and foralumab is the first fully human anti-CD3 mAb, which means it has a lower incidence rate and is less likely to cause an immune response than humanized or chimeric anti-CD3 mAbs. The market has been paying particular attention to the potential of anti-CD3 mAbs since Sanofi (NASDAQ: SNY) acquired Provention Bio for almost $3 billion for Provention’s anti-CD3 mAb drug Teplizumab. Teplizumab is a humanized mAb, which suggests that there could be interest in Tiziana’s fully human mAb therapy. Read more about Tiziana’s fight against multiple sclerosis. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

August 04, 2023 09:00 AM Eastern Daylight Time

Gale Force Digital Technologies Dominates Local SEO with LocalForce

GaleForce Digital Technologies

Gale Force Digital Technologies, a leading software provider, dominates the competition with its proprietary search engine optimization software. Businesses looking to optimize their local search rankings can now do so with ease and affordability thanks to the advanced local search engine optimization software, LocalForce. With its powerful tools and trusted data sources, businesses of all sizes can quickly improve their online visibility and maximize their organic search results. LocalForce is designed to build a vast online presence for any business and make sure it is seen by as many potential customers as possible. It does this by providing an easy way to manage location data across hundreds of directory listings, map listings, and organic search results. This ensures that customers searching for products and services in a specific area will be able to find them easily. The application also offers access to trusted data sources from major websites that provide local citations. This means businesses can be confident that their location data is being made available from the most authoritative sources on the web. Other local SEO platforms can be costly and often overcharge for directory listings, but LocalForce ensures that marketing agencies and businesses pay a fair price for these authoritative, trusted listings. Location managers don’t have to worry about claiming multiple profiles or verifying data accuracy when using LocalForce, either. Its bulk editing features allow users to quickly manage one or thousands of locations at once with minimal effort or time investment. With features like these in place and regular improvements being made by the GaleForce team, LocalForce is poised to make further strides to permanently alter the SEO management landscape for good. About Gale Force Digital Technologies Headquartered in West Palm Beach, Florida, Gale Force Digital Technologies has been providing advanced media planning software, digital marketing tools, and other solutions since 2014. The products offered are GaleForceMedia, a media planning and buying tool; LocalForce, a local search management solution; ClickForce, a paid search advertising platform; SocialForce, a multi-platform management software for managing social profiles and scheduling posts; AdForce, a programmatic digital media buying solution; and ReForce, a proprietary review generation and reputation management platform. GaleForce is continually crafting and refining products to better serve its ever-growing client base. Contact Details Gale Force Digital Technologies Gale Force PR Department +1 866-233-8499 pr@galeforcedigital.com Company Website https://galeforcedigital.com/?utm_source=news_direct&utm_medium=pr&utm_campaign=localforce_08-04-23

August 04, 2023 08:30 AM Eastern Daylight Time

News Release

ChatGPT Shares 3 Reasons Why Shiba Inu, Pepe and Pomerdoge Are In Line For 40x Gains

Blockchain Digest

ChatGPT is a powerful AI tool gaining popularity even in crypto. Recent predictions have shown that ChatGPT is capable of great analysis. After feeding ChatGPT the latest info on Shiba Inu (SHIB), Pepe (PEPE), and Pomerdoge (POMD), it gave 3 reasons why these coins are well positioned for 40x gains. Click Here To Find Out More About The Pomerdoge (POMD) Presale Chat GPT Prediction For Shiba Inu Shiba Inu is a meme-based cryptocurrency that has become popular and gained attention due to its resemblance to Dogecoin. The developers created Shiba Inu as a test of decentralized community building and attempted to copy Dogecoin's success. ChatGPT predicts that Shiba Inu will see 40x gains because of its meme coin status. It gained popularity as a meme-coin through internet memes and social media, attracting a cultured community. Additionally, Shiba Inu has attracted a lot of attention from the public, building a community but maintaining this enthusiasm is essential for growth in the future. Finally, the coin operates on the Ethereum blockchain allowing for greater adaptability. What ChatGPT Has To Say About Pepe The cryptocurrency Pepe was first linked to the Pepe the Frog internet meme. The meme coin first gained popularity in April and made a few Pepe millionaires, but it has since faded from sight. Although the frenzy has been waning over time, ChatGPT has these 3 reasons to give on why Pepe is still on the way to more gains. Firstly, inspired by the famous Frog meme, the token aims to attract attention and community following in crypto projects. Secondly, the large market cap it accumulated since its launch Lastly, Pepe Coin is listed on different CEX and DEX. 3 Reasons Why Pomerdoge Will See 40x Gains Pomerdoge is a new peer-to-peer (P2P) cryptocurrency initiative that connects gamers worldwide through a distinctive gaming experience. The project seeks to take over the memecoin industry with its unique gameplay and possibilities for huge incentives. Firstly, the unique use cases of Pomerdoge make it stand out. With its Play-to-Earn (P2E) game concept, it aims to engage players worldwide. This unique feature can draw individuals looking for engaging activities and rewards. Secondly, it has a limited token supply of 1,777,777,777 POMD. Shiba Inu and Pepe, on the other hand, have a greater supply of 589,589,040,239,380 SHIB and 420,690,000,000,000, respectively, which affects the token's potential for price growth. Lastly, secure and transparent transactions give Pomerdoge an edge. Cooperation with Cyberscope and Solidproof for audits indicates the company's dedication to security and openness. Investors can now have more faith in the project's originality as a result. Find out more about the Pomerdoge (POMD) Presale Today Website: https://pomerdoge.com/ Telegram Community: https://t.me/pomerdoge Contact Details Pomerdoge marketing@pomerdoge.com

August 04, 2023 08:15 AM Eastern Daylight Time

News Release

Revolutionizing consumer insights: CEO reveals Near Intelligence's data-driven success story

Near Intelligence

Near Intelligence CEO Anil Mathews takes Proactive's Stephen Gunnion through the company's innovative data-driven platform. Established in 2012, Near employs vast data volumes to comprehend consumer behavior across digital and physical realms, ensuring privacy compliance through anonymization and aggregation. Boasting 1.6 billion monthly active user IDs from 44 countries, the company analyzes behavior around visited places and connected devices. Near Intelligence's offerings revolve around three pillars: data, privacy, and AI-driven insights. The firm caters to various industries, including retailers, real estate, restaurant chains, and media companies. Notably, Near recently signed a significant deal with a large retailer, aiding it in identifying optimal catchment areas and attracting the right audience while gauging competition. For real estate, Near provides geospatial consumer insights, vital post-pandemic for pricing commercial properties accurately based on evolving behavior patterns. Additionally, the company collaborates with data owners, enhancing their datasets by integrating Near's physical and digital world understanding. The CEO anticipates AI's prominent role in Near's future endeavors and highlights the revamped Near.com website for accessible content. Moving forward, Near Intelligence is dedicated to upholding privacy regulations across global regions and advancing insights generation without compromising privacy. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

August 03, 2023 02:30 PM Eastern Daylight Time

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News Release

Cepton discusses national security and cybersecurity concerns in LiDAR industry

Cepton Inc

Brunno Moretti, vice president of product at Cepton Inc, discusses the implications of potential action against Chinese LiDAR companies by Washington in an interview with Proactive's Stephen Gunnion. Moretti highlights two main concerns: national security and cybersecurity. LiDAR technology is crucial for creating high-definition maps around vehicles, but if parts are produced by state-backed entities from non-allied countries, there are risks related to data security and mapping sensitive areas. Moretti also emphasizes the importance of a level playing field in the LiDAR industry and the need to ensure fair competition by preventing state-subsidized companies from gaining an unfair advantage. Cepton is part of the LiDAR Coalition, which includes US and US ally-based companies aiming to raise these concerns with lawmakers. Moretti underlines the significance of this discussion, especially as LiDAR technology is just emerging in the automotive sector. He concludes by reaffirming Cepton's commitment to safety and consumer awareness regarding the technology embedded in their vehicles. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

August 03, 2023 02:08 PM Eastern Daylight Time

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Temporal Appoints Preeti Somal as Senior Vice President of Engineering

Temporal

Temporal, the leader in durable execution, today announced that Preeti Somal has been appointed as Senior Vice President of Engineering, reporting directly to co-founder and CTO, Samar Abbas. Over the past 8 months, Temporal has built momentum, bringing on over 450 customers to their managed service, Temporal Cloud. Somal joins at this key inflection point to help drive the efficient delivery of the key product capabilities that meet the needs of their growing open source community and speed adoption of their durable execution platform. “Preeti is an exceptionally talented engineering leader,” said Abbas. “She brings a unique breadth and depth of enterprise experience and leadership skills to our team. Her work at HashiCorp and Yahoo is perfectly suited to our core mission: helping our customers make their applications more reliable and easier to maintain, while delivering more features faster. We’re thrilled she’s joining us, as we enter a new era where demand for durable execution is exploding across virtually every sector.” Over the past half year, Temporal has attracted hundreds of organizations to adopt their managed service and Somal’s hire will help the company effectively scale to meet the step change in market demand for distributed systems reliability. Today there is tremendous demand for fault-tolerant applications, not just from developer-centric organizations but from small startups through large enterprise organizations, across a wide array of industries. Temporal allows these development teams to focus on business logic and not the complexities of distributed systems. While Temporal was initially built for highly technical organizations with large teams of software developers, now there is widespread demand from more traditional and game changing startups as well. For example, Netflix, Descript, Yum! Brands, Instacart, Comcast, and Snap all bet some of their critical systems on Temporal, which empowers these businesses to build scalable applications with ease, streamlining operations and maximizing developer productivity. “Temporal meets all the elements of what excites me most in an engineering leadership role,” said Somal. “Having been introduced to Temporal while at HashiCorp, I know first-hand the critical role Temporal plays in delivering reliable applications faster. And Temporal has quickly built an incredible community – with tens of thousands of developers worldwide. The list of organizations that use Temporal is truly remarkable, and it’s growing every single day. I feel fortunate to lead the Temporal engineering team at a time when we’re so well positioned for explosive growth.” Somal joins Temporal from HashiCorp, where she led the engineering, security and IT organizations during a period of high growth. She also led research and development at Yahoo! as Vice President of Cloud Services for four years. Prior to Yahoo!, Somal spent five years at VMware as Vice President of R&D. About Temporal: Temporal is a durable execution system that enables developers to build reliable software services and applications. It allows teams to manage an application's state at scale, monitor the execution of application logic in real-time, and push updates and changes without downtime. Platform and application teams at companies like Netflix, Snap, Stripe, and Coinbase use Temporal to run application functions as workflows that inherit scalability, durability, and fault tolerance. Learn more at temporal.io Contact Details Forrest Carman +1 206-859-3118 forrestc@owenmedia.com Company Website https://temporal.io/

August 03, 2023 09:00 AM Pacific Daylight Time

Matt Mehlbrech Awarded 2023 Colorado ORBIE Award for CIO of the Year

CoorsTek

CoorsTek is proud to announce that Vice President of Information Technology Matt Mehlbrech has been named winner of the 2023 Colorado ORBIE® Award for CIO of the Year. The Colorado ORBIE Awards, presented by ColoradoCIO, honor chief information officers who have demonstrated excellence in technology leadership. ColoradoCIO recognized technology executives in six key categories – Leadership, Global, Large Enterprise, Enterprise, Large Corporate, & Corporate. Mehlbrech was the winner in the Large Enterprise category. The Awards were presented on July 28, 2023 at the Colorado ORBIE Awards event at the Hyatt Regency Denver. “I am honored to be recognized with this award and inspired by the other winners and finalists,” said Mehlbrech. “This award would not be possible without the hard work and dedication of the entire CoorsTek IT organization, who works tirelessly to support CoorsTek’s company objectives on a daily basis.” CoorsTek Chief People and Systems Officer Irma Lockridge commended Mehlbrech for the award and recognized him for the contributions that resulted in the honor. “All of us at CoorsTek are very proud of Matt and thank him for the positive impact he continues to make,” said Lockridge. “In his six-year tenure with the company, he and his organization have done a tremendous job of modernizing the tools that support our back office, our infrastructure, our security posture and overall enhancement of business intelligence platforms that help us make more informed decisions. Matt has built a strong team of talented individuals that have taken these strategic initiatives to the next level.” The ORBIE Awards is the premier technology executive recognition program in the United States. Since inception in 1998, over 700 technology leaders have received the prestigious ORBIE Award. Finalists and winners are selected by an independent peer review process, led by prior ORBIE recipients, based upon: Leadership and management effectiveness Business value created by technology innovation Engagement in industry and community endeavors About CoorsTek CoorsTek is a privately-held leading global supplier of technical ceramics, serving a wide array of industries and markets – with the vision of making the world measurably better. The company is headquartered in Golden, Colorado, with approximately 5,000 employees worldwide. CoorsTek continues to make significant investments in developing advanced materials and processes for critical applications and is the partner of choice for companies worldwide, whose success requires the unique, high-performance properties of products manufactured from engineered ceramics and advanced materials. The company is committed to delivering outstanding value through operational excellence, research, development, and manufacturing capabilities and collaborative stakeholder relationships. Learn more at www.coorstek.com. Contact Details Holly Leiker +1 303-475-1690 hleiker@coorstek.com Company Website https://www.coorstek.com

August 03, 2023 10:00 AM Mountain Daylight Time

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xUTILITY to Lead the Way Integrating Research and Patient Care

xCures

xCures, a trailblazer in healthcare technology, is delighted to unveil xUTILITY, a solution poised to transform the patient registry paradigm in the United States. xUTILITY establishes an instantaneous patient registry platform by retrieving records nationwide and automatically digitizing and structuring the electronic health data into a common data model with AI-enhanced abstraction and source verification, as needed. In order to provide a 360-degree view of patient health, xUTILITY includes comprehensive capture capabilities for Electronic Health Records (EHR) and Social Determinants of Health (SDOH) data. "The integration of research and care is the future of healthcare," said Mika Newton, CEO of xCures. "xUTILITY brings this future to the present by delivering rich, comprehensive, and timely patient data. This connectivity will spur personalized, efficient care and groundbreaking medical discoveries." The platform's ability to capture Real-Time, Regulatory-Grade Clinical Data (RRC) is pivotal to delivering quality patient care and pursuing groundbreaking medical research. xUTILITY's distinctive feature is its ability to accommodate user document uploads, integrated with automated data extraction. The resulting synchronized data architecture introduces a new era of research-driven patient care. Its innovative data extraction process, bolstered by a complete data annotation workflow, adheres to 21 CFR Part 11, signifying xCures' unyielding commitment to data integrity. The unprecedented level of automation offered by xUTILITY translates to a remarkable workforce multiplier, with up to a 30-fold improvement in efficiency of data curation. This efficiency enables healthcare organizations to expedite decision-making, improve health outcomes, and enhance operational effectiveness. With xUTILITY, xCures is charting a course toward a future where the integration of research and care forms the backbone of healthcare delivery. About xCures xCures Inc. operates an AI-assisted platform that automatically retrieves medical records from all sites of care. The (unstructured) data is aggregated and organized into a powerful, always up-to-date care summary that helps cancer patients get the right therapy at the right time. The platform's portals, xINFORM for patients and xDECIDE for providers, facilitate treatment option decisions. The research portal, xUTILITY, generates Real-time, Regulatory-grade, Clinical data (RRC) for studies and decentralized trials. For more information, contact info@xcures.com or visit http://www.xcures.com. Contact Details xCures Inc Patrick van der Valk pvandervalk@xcures.com Company Website https://xcures.com

August 03, 2023 09:06 AM Eastern Daylight Time

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ToolsGroup Named a Notable Vendor in the Gartner® Midmarket Context: Magic Quadrant™ for Supply Chain Planning Solutions

ToolsGroup

ToolsGroup, a global leader in retail and supply chain planning and optimization software, is proud to announce it has been named among ten Notable Vendors included in Gartner’s Midmarket Context: Magic Quadrant for Supply Chain Planning Solutions (July 2023). According to Gartner, “The SCP solution software market that supports midmarket enterprises consists of solutions that are cost-effective, user-focused and fast to deploy. The vendors included in this report all met the criteria of earning 60% or more of their 2021 revenue from midmarket enterprises with 100 to 999 employees or $50 million to $3 billion in revenue.” ToolsGroup’s continued focus on customers has driven technological innovations that make its solutions invaluable to midmarket companies. With a complete set of out-of-the-box capabilities for demand planning, inventory optimization, and replenishment, companies experience shorter time to implement and faster time to value. ToolsGroup helps customers outperform the competition, thanks to four major differentiators: · A dynamic data unification platform that enables end-to-end supply chain visibility and digital supply chain twins for more strategic planning · Probabilistic demand and supply planning that prepares supply chain teams for uncertainty and disruption in order to ensure continued customer satisfaction · AI-powered demand planning and automated inventory optimization for improved planner productivity and efficiency · A powerful multi-echelon inventory optimization model designed specifically for complex supply networks for reduced inventory and greater profitability Thanks to these capabilities, ToolsGroup customers experience a 20-30% reduction in inventory while achieving 99+% product availability. “We’re excited to be recognized by Gartner,” said ToolsGroup CEO, Inna Kuznetsova. “Supply chain leaders recognize the importance of automation and usability when skilled resources are scarce, as well as the business resilience linked to our unique probabilistic planning approach. ToolsGroup helps supply chain teams make better, faster decisions and provides the power to pivot and adapt successfully to disruptions and volatility.” Learn more about ToolsGroup’s award-winning, customer-centric supply chain planning solutions HERE. Gartner Disclaimer GARTNER is a registered trademark and service mark of Gartner, Inc. and/or its affiliates in the U.S. and internationally and is used herein with permission. All rights reserved. Magic Quadrant is a registered trademark of Gartner, Inc. and/or its affiliates and is used herein with permission. All rights reserved. Gartner does not endorse any vendor, product or service depicted in its research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner’s research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose. About ToolsGroup ToolsGroup’s innovative AI-powered solutions enable retailers, distributors, and manufacturers to navigate through supply chain uncertainty. Our retail and supply chain planning suites empower a new level of intelligent decision making and unlock powerful business improvements in forecast accuracy, service levels, and inventory - delighting customers and achieving financial and ESG KPIs. Stay in touch with ToolsGroup on LinkedIn, Twitter, YouTube, or visit www.toolsgroup.com. Contact Details Meir Kahtan +1 917-864-0800 mkahtan@rcn.com Company Website https://www.toolsgroup.com

August 03, 2023 08:30 AM Eastern Daylight Time

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