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Mighty Mitochondria: This Company is Developing A Novel Drug for Kidney Disease By Targeting The Powerhouse Of Human Cells

Unicycive Therapeautics, Inc.

You may remember learning that mitochondria are the powerhouse of the cells, but do you know the dangers that result if these cell superheroes get sick? In addition to powering healthy cells, mitochondria are also important players in certain diseases. This is especially true in kidney disease. While kidney cells make up only 1% of our body weight, they consume over 10% of our daily energy supply. When either acute or chronic disease strikes these vital organs, the health of the mitochondria can literally be the difference between life and death. Specialized pores inside the mitochondria called mitochondrial permeability transition (MPT) pores regulate programmed cell death—or apoptosis. Under disease conditions, MPT pores are stuck open allowing fluid to rush in causing swelling which leads to the death of the cell. What if you could close these pores? Would that restore the normal function of damaged mitochondria and possibly be a cure for disease? That’s just what a California-based biotechnology company specializing in diseases of the kidney is hoping to do. Unicycive Therapeutics Inc. (NASDAQ: UNCY) recently announced findings from a preclinical trial for their drug called UNI-494 that reduced a known biomarker of ischemic injury that is present in acute kidney injury (AKI), a result described as “very encouraging” by a leading expert in the field of AKI research. UNI-494 is a potent activator of the mitochondrial adenosine triphosphate-sensitive (ATP) potassium channel (mitoKATP). That’s important because when these channels are activated, they close the MPT pores and prevent the damage that leads to cell death. Mitochondrial dysfunction is closely associated with kidney issues, including (AKI). Affecting over 13 million people worldwide each year, AKI increases the risk of mortality by 23.9% in adults and 13.8% in children. Companies like DaVita Inc. (NYSE: DVA) and Akebia Therapeutics Inc. (NASDAQ: AKBA) are among the companies seeking solutions to a variety of renal diseases. Unbelievably, however, there are still no Food and Drug Administration (FDA)-approved drugs for AKI. Sadly, damage to mitochondria is seen in other diseases as well, including cardiovascular, liver and eye degeneration. While Unicycive is initially focused on producing a treatment for AKI and chronic kidney disease (CKD), it believes that the mechanism of action of UNI-494 may also be applicable for the treatment of other diseases where the mitochondria are affected. The company is now beginning its next milestone, filing to begin Phase 1 human trials of the drug. “We are excited to report this key finding,” Unicycive CEO Dr. Shalabh Gupta said. “We remain on track to file a regulatory submission by the end of 2022 that will allow us to initiate our Phase 1 study with UNI-494.” If the FDA approves the drug, it would be the first drug for AKI available on the market. Unicycive Therapeutics is a biotechnology company developing novel treatments for kidney diseases. Unicycive’s lead drug, Renazorb, is a novel phosphate binding agent being developed for the treatment of hyperphosphatemia. UNI-494 is a patent-protected new chemical entity in late preclinical development for the treatment of acute kidney injury. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Anne Marie Fields - Stern Investor Relations +1 212-362-1200 annemarie.fields@sternir.com Company Website https://unicycive.com/

October 12, 2022 08:00 AM Eastern Daylight Time

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How Trauma Can Affect Disaster Survivors

The Chicago School of Professional Psychology

Beyond the physical devastation of hurricanes, floods, earthquakes and other natural disasters, there could be emotional and psychological trauma with long-lasting impact. According to the National Institute of Health, the negative mental health effects of a disaster such as Hurricane Ian are not unusual, especially among children, women and the dependent elderly population who suddenly feel even more vulnerable. “Any disaster has the potential to trigger psychological/emotional distress and even post-traumatic stress, depression, anxiety, and other mental health disorders,” said Dr. Michele Nealon, Psy.D., President of The Chicago School of Professional Psychology. “Studies show that suicide can increase 23 percent or more after a catastrophic event and minor symptoms can quickly escalate.” Dr. Nealon says disaster survivors may experience many different signs and symptoms, including: Reliving the traumatic event as if it were happening again (flashbacks) Upsetting dreams or nightmares about the traumatic event Avoiding thinking or talking about places, activities or people that remind you of the traumatic event Negative thoughts about yourself, other people or the world Lack of interest in activities you once enjoyed Trouble sleeping, eating or concentrating For children 6 years old and younger, signs and symptoms may also include: Re-enacting the traumatic event or aspects of the traumatic event through play Frightening dreams that may or may not include aspects of the traumatic event Anyone experiencing any of these symptoms, should be encouraged to check in with a mental health professional or their primary care physician to access the support they need, advises Dr. Nealon. “For the thousands who are affected by something like Hurricane Ian--many of whom live in rural areas or are from underprivileged communities-- access to counselors and psychologists may be difficult. As natural disasters continue to increase and worsen, we need to do a better job of ensuring that survivors can get the services they need. Developing the mental health pipeline of diverse mental health practitioners is more important than ever before,” she said. About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. To spark positive change in the world where it matters most, The Chicago School has continued to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of domestic and international professional partnerships, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is proud to be a part of TCS Education System, a nonprofit, integrated system of colleges and universities that works collaboratively to advance student success and community impact. To learn more, visit www.thechicagoschool.edu. # Contact Details The Chicago School of Professional Psychology vivien +1 323-893-4743 vhao@thechicagoschool.edu

October 11, 2022 01:00 PM Pacific Daylight Time

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New PathPresenter Website Features Pathologist-built Enterprise Image Sharing Platform for Clinical Care, Education, and Research

PathPresenter

PathPresenter, the image sharing platform for pathology, today announced the launch of its new website ( www.pathpresenter.com ). The site focuses on PathPresenter’s enterprise workflow platform, trusted by more than 25 tier-one institutions around the world for clinical care, education, and research. The informational website complements PathPresenter’s popular public imaging sharing platform, which has a global community of 45,000+ users in 172 countries. The new website highlights PathPresenter’s end-to-end enterprise solution and how it benefits pathologists, clinicians, researchers, and institutions in three key areas of pathology practice: Clinical Care: A pathologist-built enterprise platform empowering pathologists to receive, view, and sign out cases from their institution – or from cases uploaded from around the world – directly in their institution’s existing LIS, bringing the control and organization of the clinical workflow back to the end user. Education: The most comprehensive platform available to bring pathology curriculum to digital life for academic medical centers, reference labs, pharma companies, and AI vendors. Research: A powerful platform enabling researchers to collaborate globally, through centralizing the collection of annotations, labels, and slide level metadata across institutional datasets. At the core of the platform is PathPresenter Exchange, a powerful image management system that manages all aspects of the workflow – from scanner-agnostic WSI upload and quality control to lag-free image viewing, HL7 communications with institution LIS systems, and seamless integration with 3 rd party AI models. The enterprise platform is supported by over 100,000+ hours of real-world usage on Microsoft Azure Cloud, 24/7 monitoring by Vanta for HIPAA compliance, and successful deployments in multiple international high security and compliance institutions. Complementing the new website site is a growing Learn section, which features articles, news, blog, publication, and webinars and events. “Increasingly, pathologists, clinicians, researchers, and institutions are seeking out digital workflow that is practical and easily integrated with 3 rd party tools and the institution’s existing infrastructure,” said Patrick Myles, CEO of PathPresenter. “With a platform that is guided and built by pathologists, we are creating a dynamic ecosystem to better serve patients, train the next generation of digital pathologists, and share and spread pathology knowledge across the globe.” About PathPresenter PathPresenter is the image sharing platform for pathology, on a mission to democratize access to the world’s pathology knowledge by connecting pathologists to the vast expertise of their colleagues globally and providing a practical platform to access and use best-in-class AI models. Founded in 2017 by dermatopathologist and digital pathology pioneer, Dr. Rajendra Singh, PathPresenter has been adopted by 25+ tier one medical institutions for clinical care, education, and research, and has built a thriving community of 45,000+ users in 172 countries to easily view and share digital pathology images and knowledge. For more information visit www.pathpresenter.com. Contact Details Cory Batenchuk +1 873-355-9913 cory@pathpresenter.com Company Website https://pathpresenter.net

October 10, 2022 12:15 PM Eastern Daylight Time

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PathPresenter Founder, Dr. Rajendra Singh, Honored by the College of American Pathologists with Lifetime Achievement Award

PathPresenter

PathPresenter founder, Dr. Rajendra Singh, MD, FCAP, has been honored by the College of American Pathologists (CAP) with a lifetime achievement award in recognition of his commitment and dedication to improve the pathology education process and bring it to a new, advanced level using digital pathology. Dr. Singh is a dermatopathologist and founder of PathPresenter, the image sharing platform for pathology, with more than 45,000 users in 172 countries that’s used by more than 25+ academic departments, private pathology groups, and organizations around the world for clinical care, education, and research. His invaluable contributions to teaching residents and fellows earned him the Icahn School of Medicine’s Teacher of the Year Award for five consecutive years. Dr. Singh is a role model to many and a mentor for trainees in the US and outside its borders. During his appointment at Mount Sinai Hospital and Northwell Health, Dr. Singh used his educational platform to advance the implementation of digital pathology, to great effect and general approval. He has proven to be an excellent leader in pathology and was named to The Pathologist magazine’s Power List in 2020, 2021, and 2022. “We developed PathPresenter to create an ecosystem for pathologists, clinicians, researchers and industry to come together and provide innovative digital solutions in pathology,” commented Dr. Rajendra Singh, founder of PathPresenter. “We are pleased and honored to see how the platform has been able to better serve our patients, train new doctors, and share and spread pathology knowledge.” Established in 2006, the CAP Lifetime Achievement Award recognizes and honors members who have made a broad and positive impact on the pathology profession through contributions to one or more areas of the organization over an extended period. Dr. Singh received the award at the recent CAP annual meeting in New Orleans. About PathPresenter PathPresenter is the image sharing platform for pathology, on a mission to democratize access to the world’s pathology knowledge by connecting pathologists to the vast expertise of their colleagues globally and providing a practical platform to access and use best-in-class AI models. Founded in 2017 by dermatopathologist and digital pathology pioneer, Dr. Rajendra Singh, PathPresenter has been adopted by 25+ tier one medical institutions for clinical care, education, and research, and has built a thriving community of 45,000+ users in 172 countries to easily view and share digital pathology images and knowledge. For more information visit www.pathpresenter.com. Contact Details Cory Batenchuk +1 873-355-9913 cory@pathpresenter.com Company Website https://pathpresenter.net

October 10, 2022 12:07 PM Eastern Daylight Time

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New Drugs And Therapies Are Giving MS And ALS Sufferers New Hope

Pasithea Therapeutics Corp.

People suffering from incurable neurological diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) hope new therapies and drugs will arrive sooner than later. A chronic and inflammatory neurodegenerative disease, MS affects 400,000 people in the United States and 2.1 million people worldwide, according to the latest data from the National Institutes of Health (NIH). Affecting quality of life, employment, social relationships, and productivity, MS costs the U.S. healthcare system anywhere from $8,528 to $52,244 per patient per year. MS is a potentially disabling disease affecting the brain and spinal cord — the body’s central nervous system. The immune system of those with MS attacks the myelin, the protective sheath covering a person’s nerve fibers. It interrupts communication between the brain and the functions of the body. The end result for many people is permanent damage or deterioration of the nerves. Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently, while others may experience long periods of remission without new symptoms. Recent ALS Research Spurs Optimism Although there is no recent data revealing the number of people in the U.S. affected by ALS, an estimated 31,000 people have the condition and an average of 5,000 new patients are diagnosed each year, according to 2017 statistics from the Centers for Disease Control and Prevention. Age-related ALS mainly strikes people between 55 and 75 who live only two to five years after symptoms develop. Also called Lou Gehrig’s disease for the New York Yankee great who died of ALS in 1941, the disease belongs to a broader group of disorders known as motor neuron diseases which cause the gradual deterioration and death of motor neurons. Motor neurons are nerve cells extending from the brain to the spinal cord and muscles throughout the body. As motor neurons degenerate, they stop sending messages to the muscles, which gradually grow weaker, twitch and suffer from atrophy. Eventually, the brain loses its ability to initiate and control most voluntary movements such as walking, chewing, and talking. Merck & Co. Inc. (NYSE: MRK) recently announced it’s paying $25 million to kick off a research partnership with biotech startup Cerevance, which analyzes donor brain tissue to find novel targets for new drugs for neurological disorders. Cerevance’s best-known program is geared toward another incurable neurological disease — Parkinson’s — but Merck will determine whether the technology can help it discover and develop new drugs to treat Alzheimer’s disease. Recent news in the MS research space touted Clene Inc. ’s (NASDAQ: CLNN) results from its Phase 2 VISIONARY-MS trial of CNM-Au8, an investigational gold nanocrystal suspension. The trial began before COVID-19 and ended prematurely, limiting enrollment to 73 of the 150 planned participants. Pasithea Advances Trials For MS And ALS Pasithea Therapeutics Corp. (NASDAQ: KTTA), a biotechnology company focused on researching and discovering new and effective treatments for psychiatric and neurological disorders, announced its investigational MS vaccine PAS002. Trials of the vaccine have effectively delayed disease onset and reduced disease severity in a mouse model of the neurodegenerative condition, according to its preclinical study data. The vaccine, designed to promote immune tolerance to a specific myelin protein, also reduced the severity of relapses and helped the animals gain weight, indicating a better overall health status. “Although early-stage data, we’re thrilled with the results of this study and the strong preclinical efficacy data of our tolerizing approach,” Pasithea CEO Dr. Tiago Reis said. Pasithea Therapeutics has also recently received a $700,000 grant to further its research into anti-integrin antibodies as potential treatments for ALS. The company is developing a monoclonal antibody (mAbs) for treating ALS and other neuroinflammatory disorders. A particular integrin, called alpha-5/beta-1 or fibronectin receptor, has been found at high levels in certain immune cells in an animal model of ALS carrying mutations in the SOD1 gene. Mutations in this gene are estimated to account for up to 20% of familial ALS cases and up to 3% of sporadic ALS cases. The Alpha-5/beta 1 study found that integrin expression is significantly increased in ALS animal models and post-mortem human ALS and significantly upregulated with disease progression. Pasithea has multiple monoclonal antibody candidates against the alpha-5/beta-1 integrin. Treatment with these antibodies has extended survival and improved motor function in the SOD1 mice model of ALS, suggesting a novel mechanism to treat patients with ALS. For more information on Pasithea Therapeutics, visit www.pasithea.com. Pasithea Therapeutics Corporation is a biotechnology company focused on the discovery, research and development of new and effective treatments for central nervous system (CNS) disorders. With an experienced team of experts in the fields of neuroscience and psychopharmacology, Pasithea is developing new molecular entities for the treatment of psychiatric and neurological disorders, including Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS). Pasithea addresses the needs of patients currently suffering with mental illness by providing access to IV ketamine infusions both in clinics and in-home settings. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details TraDigital IR- Camille Baptiste camille@tradigitalir.com Company Website https://www.pasithea.com/

October 10, 2022 09:39 AM Eastern Daylight Time

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Hong Kong Baptist University research unveils association between plasma metabolites and COVID-19 antibody levels in recovered patients

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 10 October 2022 - A study led by Hong Kong Baptist University (HKBU) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called glycylproline (gly-pro) and its producing enzyme. A research team led by Professor Cai Zongwei (left) and Dr Yang Zhu (right) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called gly-pro and its producing enzyme. The researchers also found that the application of an inhibiting agent can counteract the activities of gly-pro and its producing enzyme, and this helped to maintain COVID-19 antibody levels in a mouse model. The findings offer important insights that could aid the development of novel therapeutic and vaccination strategies against the virus. The research results have been published in the Proceedings of the National Academy of Sciences (PNAS), a renowned international scientific journal. Antibody levels drop in some recovered COVID-19 patients The levels of COVID-19 antibodies among individuals in a community are crucial for herd immunity against the virus. In general, recovered COVID-19 patients have high antibody levels as a result of their natural immune reactions. However, antibody levels in some recovered COVID-19 patients have been seen to drop rapidly over the course of a few weeks, and the underlying mechanism of this phenomenon remains poorly understood. Since the beginning of the pandemic, research studies have revealed changes in plasma cytokine and metabolite levels in COVID-19 patients. Based on these observations, a research team led by Professor Cai Zongwei, Chair Professor of the Department of Chemistry and Director of the State Key Laboratory of Environmental and Biological Analysis, and Dr Yang Zhu, the first author of this paper and a Research Assistant Professor of the Department of Chemistry at HKBU, investigated how plasma cytokines and metabolites are associated with antibody levels in recovered COVID-19 patients. Metabolite gly-pro associated with antibody levels The research team analysed the cytokine and metabolite profiles in the plasma samples of three subject groups. The first group included 17 recovered COVID-19 patients with steady COVID-19 antibody levels; the second group included 30 recovered COVID-19 patients with rapidly fading COVID-19 antibody levels; the third one was a control group comprising 35 individuals who had not been infected with COVID-19. A series of quantitative computational analyses that involved the use of machine learning techniques were used to compare the levels of different plasma cytokines and metabolites in the three subject groups in relation to their COVID-19 antibody levels. The researchers then compared the two recovered patient groups with the control group, and any cytokines and metabolites with significantly different levels between the two groups and the control group were shortlisted. Among the shortlisted targets, the levels of seven cytokines and 20 metabolites were seen to differ significantly between the two groups of recovered COVID-19 patients. The researchers then analysed the association between the selected cytokines and metabolites and COVID-19 antibody levels in recovered patients. From the collected data, they concluded that the plasma concentration of the metabolite gly-pro had increased the most in the two recovered patient groups compared with the control group. Overall, the levels of gly-pro in the recovered patient group with rapidly fading antibody levels were four times higher than the control group, while the levels of gly-pro in the recovered patient group with steady COVID-19 antibody levels were two-and-a-half times higher than the control group. Based on these results, the researchers investigated the relationship between COVID-19 antibody levels in recovered patients and gly-pro, as well as the producing enzyme of gly-pro which is named dipeptidyl peptidase-4 (DPP4). Inhibiting gly-pro maintains steady antibody levels The research team set up a four-week mouse model experiment to test the hypothesis that high gly-pro levels are associated with a rapid drop in COVID-19 antibody levels in recovered COVID-19 patients. Four groups of 12 mice were injected with the spike protein of the COVID-19 virus. The groups were then respectively treated with: (1) exogenous gly-pro; (2) an inhibitor that blocks the degradation of endogenous gly-pro; (3) exogenous gly-pro and a DPP4 inhibitor (Sitagliptin, which is also an anti-diabetic drug); and (4) saline. The serum COVID-19 antibody levels in all groups were similar in the first week of the experiment. The antibody levels of the mice in the first group declined after the second week, suggesting that increased gly-pro levels are associated with a decline in COVID-19 antibody levels. The antibody levels of the mice in the second group, who had relatively steady gly-pro levels, also began to decline in the third week. The slower decline in antibody levels in the second group of mice compared to the first group shows that varying amounts of gly-pro are associated with the amount of time a steady antibody level can be maintained. Meanwhile, the antibody levels of the mice in the third group remained stable throughout the experiment. This shows that when the activities of DPP4 are inhibited, the negative effects of gly-pro can be neutralised, and a steady level of COVID-19 antibodies can be maintained. New insights for therapeutic and disease control strategies Professor Cai said: “Effective shield immunity for a community against the spread of COVID-19 is highly dependent on the maintenance of steady antibody levels in individuals. Our experimental results suggest that DPP4 inhibitors can effectively maintain steady antibody levels in COVID-19-infected mice. As a result, our study offers important insights into how we can develop a similar medical approach to maintain COVID-19 antibody levels in humans, which will contribute to the global fight against the pandemic.” Dr Yang said: “Further studies based on our research findings are warranted to explore the potential in other areas of therapeutic and disease control, especially in terms of other applications. For example, novel strategies may be developed to enhance the efficiency of vaccination in boosting antibody levels in humans, particularly in diabetic patients, a well-known high-risk population for COVID-19.” Contact Details Communication and Public Relations Office, HKBU Winnie Shum +852 3411 5262 hkbunews@hkbu.edu.hk

October 10, 2022 09:00 AM Eastern Daylight Time

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Elsevier and the Society of Hospital Medicine Announce Joint Initiative Aimed at Helping Patients With Underlying Substance Use Disorders (SUD)

Elsevier

Elsevier, a global leader in evidence-based clinical practice content, research publishing and information analytics, today announced that it will partner with the Society of Hospital Medicine (SHM) in the development of materials to help hospitalists at the point-of-care with the identification, inpatient management, and discharge planning of patients with underlying substance use disorders (SUD). More than 17 million U.S. adults are affected by SUD and its underlying health conditions. As part of this initiative, Elsevier has provided grant support to enable the Society of Hospital Medicine to develop a suite of tools and resources for hospitalists that will help them in identifying patients with SUD, initiating medications for opioid use disorder (MOUD) in the hospital setting, and supporting patient discharge to the home or community. Faculty working on the project have access to evidence-based information through Elsevier’s ClinicalKey® to inform their research. At project completion, SHM will contribute to the creation of point-of-care recommendations on the topic within ClinicalKey, allowing ClinicalKey users to quickly access the information, while reinforcing best practices recommended by SHM. “Hospitalization represents an important step in identifying and treating patients with SUD,” said Josh Schoeller, President, Clinical Solutions, Elsevier. “It’s imperative to support hospitalists in acquiring the knowledge, evidence-based strategies and tools to effectively manage this patient population and address the growing health crisis in our country.” The first output of this project, due to release this year, will be a discussion guide to support hospitalists in conducting patient-centered discussions with individuals who have a diagnosis of SUD with a focus on Opioid Use Disorder (OUD) including best practices and clinical scenarios in a case study format which review how to identify patients with OUD, initiate treatment and facilitate effective transitions of care strategies. “We’re pleased to collaborate with Elsevier on this important initiative that we believe will have an impact in the health and wellbeing of many Americans suffering from substance use disorders,” said Jenna Goldstein, Director of SHM’s Center for Quality Improvement. # # # About the Society of Hospital Medicine Representing the fastest growing specialty in modern healthcare, the Society of Hospital Medicine (SHM) is celebrating 25 years as the leading medical society for hospitalists and their patients. SHM is dedicated to promoting the highest quality care for all hospitalized patients and overall excellence in the practice of hospital medicine through quality improvement, education, advocacy, and research. Over the past decade, studies have shown that hospitalists can contribute to decreased patient lengths of stay, reductions in hospital costs and readmission rates, and increased patient satisfaction. For more information about SHM and hospital medicine, visit hospitalmedicine.org. About Elsevier As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems. In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders. Elsevier employs 8,700 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on over 2,700 digitized journals, including The Lancet and Cell; our 43,000 eBook titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. Contact Details Dan DiPietro-James, Global Director, Media Relations dan.james@elsevier.com Company Website https://www.elsevier.com/en-xs

October 10, 2022 09:00 AM Eastern Daylight Time

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5 Best Resume Writing Services: Reviews of the Professional Companies Near You

Resume Builders

Getting started on a job does not come automatically. It begins with an application process for the same role. And a major part of this procedure is submitting a well-written resume. Otherwise called a CV, your resume is one of the essential documents you present in a job search or application for opportunities. As a matter of fact, it is the most important document in the entire procedure. It can make or mar your application process for that fellowship, postgraduate studies, internship, or other work-related bids. Thus, you need your resume to be in top form consistently. But here's the twist, not everyone knows how to write a resume. It is a technical document. Thus, you might find it challenging to write. In fact, if you do, sometimes you have a greater chance of shortchanging yourself. Why? Because it might not pass the ATS. That is the Application Tracking System. And guess what? Most companies now use this tech mechanism to weed through irrelevant and not-well-written resumes submitted through their application portals. Do you want to be a part of these unscreened resumes? I bet not. This is why you need to get an expert to work on your resume, don't you think? Speaking of resume-writing experts, this is what this article centers around. Oh, you will love this! We have carefully worked on a list of the best resume-writing services you could ever have. They were not chosen via random picks. No. They were chosen through a thorough process of fishing out the quality from the substandard in the market. Interestingly, many of these services are attested by the numerous positive comments and feedback on their works across many reliable review sites, such as Site Jabber and Trust Pilot. Without further ado, here is the list of the 5 best resume writing services: PaperHelp - Best resume writing service overall 101Resumes - Professional resume writers from the USA Studdit - Affordable resume writing company 99Papers - High-quality resumes for an executives Ivory Research - CV resume writing service from the UK So, you have nothing to fear. We have carefully curated this list of professional resume writing services based on the excellence of their writing, their originality, how their pricing is set, their customer service, and of course, prompt delivery of written resumes. TOP 5 Professional Resume Writing Services #1. PAPERHELP PaperHelp is a writing service that stands true to its name. They help people all around the world to craft excellently written papers to position them as top-notch candidates in their academic pursuits. For their resume works, though, their works span beyond the student environment. Having been in the market for over a decade, they are one of the most reliable platforms to meet your resume writing needs. No types of resumes are out of their reach. They can get it done for you at lightning speed. Thus, a major part of their selling point is prompt delivery. Little wonder they are referred to as the best professional resume writing service in the United States, and by extension, all regions of the world where students need resumes. Interestingly, it's not only students who need resumes. Thus, anyone is welcome to their service any day, all day. It is noteworthy that PaperHelp is an online custom writing service that offers a wide range of writing services. However, resume writing is one of their flagship services. And they have proven themselves to be an excellent place to turn to when needing a top-notch resume for your application. Their excellence in the market is directly linked to the premium quality of their resumes and CVs. Their work is distinct as they have done several times for people who patronize them. Their website is littered with well-curated positive reviews from clients in the past and present who have had their resumes written with them. You could hardly blame the clients who are enthusiastic to drop great reviews. The PaperHelp army of writers is one of the best in the market. They are professional, qualified, detailed, and hands-on. When you get to the service website to order a resume, there is always a writer ready to attend to you with the best service possible. Because these writers are Ph.D. and Masters degree holders, they are simply stellar hands on deck, ready to provide you with premium resume writing that best reflects any type of application you are looking to pursue. This team of experts efficiently works on your skills, experience, background, competencies, and accomplishments. And they present them in such an irresistible way that many recruiters have made PaperHelp clients their preferred candidates. Another interesting fact that stands PaperHelp out of the crowd is its customer service. Oh, it is remarkable. Many customers keep going back to them for their writing needs because of this reason. The high-quality nature of their client service is based on a sterling level of communication. PaperHelp customer support is available 24/7. And they make ordering for them interactive enough that you can track your order via live chat. You can also manage your order through email, SMS, the PaperHelp app, and Facebook Messenger. It gets all the more interesting to know that PaperHelp has a lot of discounts and freebies for their customers. You can get an excellent resume starting from $45. Yet, as a client, you can still get up to a 15% discount, especially if you are a first-time customer. This is apart from other referral and loyalty programs. For their referral program, it gives you up to $250 for people who use your link to place an order. This platform is also known for the free revisions that its client gets. The stunning refund policy is also not out of the equation. If you are looking to make some corrections to your resume or it so happens that you are not satisfied with their work, you can request a revision or refund. #2. 101RESUMES 101Resumes ranks high among the best resume writing services in the Unites States today. And the reason for this is simple - company based in Chicago. They have positioned themselves in the market through their quality work. So, if you are looking to get that job of your dreams and you need a reliable CV to give you leverage, you should consider reaching out to them. Ordering from them means that you would be buying from a platform that has a lot of great reviews from clients in the past and present. These feedbacks are not only from resume writing. They are also gotten via remarkable delivery on cover letters, CVs, personal statements, statements of purpose, etc. If you want to know one of the most impressive things about this 101Resumes, then the seamless ordering process will stand out. The interface is easy to navigate. It allows you to move freely and make fewer mistakes while ordering from them. By simply selecting your career level, your package, the type of job, and the appointed deadline, you are good to go. Other information in this process would include uploading your details and requirements. And with all that, you are set to order from their website. Definitely, creating an account would be needed. However, the registration and information-gathering process should take an average of 4 minutes. So, with a uniquely simple interface and stress-free ordering process, you are ready to go! Furthermore, 101Resumes has one of the market's considerably fair resume writing prices. With just $99, you can get one of the best resumes in the market written for you. And the prices, as with other online writing services, vary depending on your grade. That, the career level for which you are writing the resume would largely determine the price range with which your work would be written. But not only that, other factors could affect the price of your work. One is if the deadline for which you need the resume is shorter than the usual time that the platform stipulates that the work would be ready. Thus, you might have to pay an extra fee to fast-track the writing. Hence, the price is jerked up. Also, 101Resumes stands as a specialized company. They maintain writing solely career-related technical documents. That is, resumes, cover letters, and CVs. Thus, seeing that their expert writers are targeted in that direction, they churn out more quality works based on this expertise than other services that render additional services. So, you can be sure that more attention is paid to details. And by the way, it takes an average of 4 days for the CV to be delivered. And with this level of speed, the quality is not compromised. It sure would make you look good before any prospective employer looks through the resume. #3. STUDDIT Studdit is that one-stop shop that caters to all your writing needs and particularly provides you with excellent technical and federal resume writing services. With hundreds of reviews lauding their praise in the market, they would get your CV written from scratch or take it from where it is to where you need it to be. Their presence in the market speaks of possibilities. They have shown many new online writing services that a platform can have students and job applicants flock to their websites to get their resume writing done. And guess what? They always deliver excellently. This resume writing platform is available to take all writing services because of its team of professional freelance writers. They are simply good at what they do. Thus, it makes it easier to get high-quality work from them every time they write. A good thing here is that Studdit has a great in-house culture of treating their writers well. Thus, they are more than enthusiastic about delivering promptly as they are given tasks. Sources note that you will never be given a new order to work on as a writer unless you finish a previous one on your hands. Writers are rewarded when they bring clients to the platform. So, as a person ordering, you can rest assured that your work is being handled by people keen to do their work. Hence, you can be sure of a great writing outcome. Furthermore, if you are looking to explore a stressless option for ordering your resume online, Studdit is that place. How so? Their website makes it super-easy to get your orders across. You do not have to sweat due to complications and complexities during the ordering process. Everything is straightforward. The steps to order usually include picking the type of essay (in this case, it would be a resume), specifying the details of the resume, choosing the deadline, selecting the writer you'd like to work on your order, and lastly, providing the payment. And to cap it all up is their financial policy. They are the cheapest resume writers in the industry. With just $10, you can have a great resume delivered to you. And, of course, the price ranges depend on what you need. For example, the price mentioned above works best for high schoolers. However, for professional CVs, that would be about $20. Anyone conscious of the market's price trends, especially among online writing services, will attest to this being a low price. And it does not in any way affect the excellence of the delivery. #4. 99PAPERS 99Papers has left a strong footprint in the market as one of the strongest online writing service brands. They are not new to the space. Thus, they have many reviews to their credit. Many a client have established a trust connection with them over the years. And the reason for this is not far-fetched. It is hinged upon that they deliver premium quality jobs when their work is ordered. They are not just fundamental in their approach to customer satisfaction. They are with you every step until your job gets to the finished stage. Why are they trusted in the market? Because they have distinguished themselves when it comes to pricing, discount programs, excellent deliveries, and outstanding customer satisfaction. These are basic things to note when you want to order from any professional executive resume writing service around. The excellent delivery they pride themselves in is owing to a competent team of professional writers. And even though 99Papers has academic writing as the major aspect of their writing services, they still offer additional career-related services such as personal statements and resume writing. And with expert freelance writers from New York not being novices in the market, they are reliable to churn in excellent deliveries consistently on the platform. Another major reason most people patronize them is the pricing. With $12.60, you would get a standard resume with 15-day delivery. And for their premium plan, you get to pay $22.05 for their 15-day delivery resume. And just like many other platforms, many dynamics are at play around the pricing. A good example is a deadline. You are charged extra fees if it is shorter than what's stipulated in the service. The same goes for your career level. A high-schooler resume's price is lower than an executive-level CV. And with many customer reviews online, you will conclude that 99Papers is the hub of high-quality resumes for executives. Furthermore, this specific platform has a bidding system where you pick the writer that works on your resume. It is after this phase that you get charged on their website. And yes, they have a loyalty program that affords you a 5% discount on each resume you order. And you can make use of this discount on future orders as well. However, this discount only lasts for a total of 5 years. To get access to a lifetime discount, you might need to prep your wallet for that. #5. IVORY RESEARCH Getting the best writing done for your academic pursuits has never been easier. With Ivory Research, they take your writings from where it is to where you desire them to be. Especially Curriculum Vitae (CV), resumes, personal statements, dissertations, cover letters, theses, and other academic writings. Technical writings like these are their forte. And in the UK, they have established their brand as a valuable asset for every student and non-student seeking to get premium work done. They exist to help you achieve your academic, business, or even personal goals. Thus, they have curated a team of specialist writers who are academics themselves. This is to get the best hands to work on your military resume and other writing needs. Little wonder many of their clients are repeat customers. The quality of work delivered always brings them back. This company prides itself in on-time delivery of all the work you order from them. Their expert writers facilitate this as well. That is, this army of writers deliver excellent writing, original and plagiarism-free content, as well as prompt response to the deadline. Alongside this is the fact that they also render proofreading and editing services. So, not only can they craft your resume from scratch, but they can also help you take it from mere to exceptional. Ivory Research prides itself on a solid customer support system. You will not be left stranded as a customer reaching out to them. Many clients have become repeat customers because of the quick and detailed interaction that the Ivory research support team affords them. In the same vein, you can be sure of anonymity when you order from them. You would not be afraid of your details being found randomly online. They keep the information of their clients 100% confidential. So, if you are looking to write a stellar resume or cv and want to be kept anonymous from the writer, this is an excellent option to explore. FREQUENTLY ASKED QUESTIONS What is resume writing? Resume writing is the act of creating your resume. As simple as this sounds, it fully captures the entire process. A resume in itself is a formal document that iterates your qualifications for a specific role you are looking to apply for. It highlights the most relevant information in your career pursuits that positions you as the best candidate for the position you are applying for. It is mainly accompanied by a cover letter expressing your interest in applying for that role. Noteworthy is the fact that most recruiters advocate for resumes to be one-paged or two-paged at most. Writing a resume is a process that requires careful detailing of specifics. This information is tailored particularly to the given role being applied for. Thus, as much as you could have a general resume, it is advisable to have specific resumes for each job application. The writers in these services help you highlight the best possible qualifications, background information, job history, certifications, and other details that make you a perfect fit for the role you are looking to occupy. They take your information and convert it into a page that helps to endear you to the recruiter. Resume writing involves some form of technical templates to follow. Many recruiters will prefer it to be chronological. That is, it contains your recent job history in the order you took them on, as it relates to the current role. Also, it includes neatly arranged headings and sub-headings, margins, active language uses, and highlights of important achievements. Note that a resume makes use of professional fonts. How much does it cost to hire someone to write a resume? First, hiring someone to write a resume is a promising venture everyone should invest in. However, how much that costs now depends on each writer hired to write the resume. To write your resume, each writing service charges differently. However, one thing that stays consistent is the excellence of the delivery. The price also differs based on the peculiarities of the work. For instance, the price of writing a resume with a shorter deadline would be different than that which was delivered on the number of days stipulated by the writing platform. The same goes for the type of grade the resume is written for. The career level is a major determinant of the price range of hiring a writer on some of these professional writing services to craft an excellent resume. The price for a high schooler is way less than that of an executive client. Further, as noted earlier, different companies write resumes for different prices. 99Papers, for example, writes theirs for $12.60 with a 15-day delivery timeline. While with PaperHelp, you can get an excellent resume starting from $45. For Studdit, their price for a professional resume is about $20. So, it all boils down to checking out what platform works best for you. Their offering for their prices also matters. So, how much you should pay a resume service near you is not fixed or static. It depends on what each writing service offers and if you can get more for less. Is it worth paying for resume service? Definitely! One might even say it is more than worth paying for resume service. Writing a resume is a technical job. And thus, it requires a lot of expertise to be done well. Just like a dissertation, you might be low on chances of scoring high if you are writing it for the first time, with little prior knowledge on how to go about it. However, if an experienced writer takes on the job for you, your chances of being an A student drastically increase. Similarly, a resume is a major document you need to get the job of your dreams. So, if it is done shabbily, you might not get the desired result of getting a good flavor from the recruiter. It just makes sense, doesn't it? If you do not have the capacity or required skillset, you outsource it to persons who are experts at it. Thus, you position yourself to enjoy the results of getting your resume written by a specialist. Many writers in the writing services listed above have crafted CVs and resumes that landed a job for clients. Thus, it makes it worth it to pay for resume services. What is the best resume writing service in 2022? There are many writing services in the market. But one that stands out among the pack is PaperHelp. They are the best resume services near me and you in 2022. And the reason for their distinctiveness is not hard to decipher. They take their clients' satisfaction seriously. They are one of the oldest in the market. With 12 years of experience in the industry, they have serviced many customers who have gone on to land high-paying jobs. Their sea of professional writers creates stunning CVs, which help to attract recruiters. These writers are not aimlessly chosen. They undergo a strict recruitment process where only the best fit for the job is chosen. So, the people who are hands-on to serve you on the PaperHelp platform are the best of the best writing specialists hands available. Further, PaperHelp’s customer support is one of the best around. You are never in the dark about the progress of your work. You are given adequate feedback per time on where your work has gotten to. And you get to manage your order through email, SMS, the PaperHelp app, and via Facebook Messenger. What is the affordable resume writing service? Pricing for each writing platform is different. And as noted above, there are many factors responsible for different price changes and jerks. However, in the resume writing service industry today, the most affordable remains Studdit. With $20, you get an exceptionally high-quality resume delivered to you. And, of course, like many other platforms, customized deadlines, client requirements, and career levels can increase this price. However, you could have a standard resume written for you by an expert writer for just $10. And you will not worry about less quality. Some of their writers deliver ahead of the delivery date and still get a stellar job done. Thus, you are still provided with high-quality work with the super-cheap payment. And alongside these are freebies and several discounts their clients enjoy. For example, you can get up to 15% discount on your first purchase with them. Further, you have excellent customer support throughout your ordering journey with them. What is the best resume writing service in Australia? If you are a student or job applicant in Australia, a very reliable platform to get your resume written is 99Papers. Many things make them significant for the Australian market. One is that their professional writers write in English as their native language. Thus, details of a good command of the language, which recruiters look out for in your resume, will be well covered-for in the entire document. Further, 99Papers provides quality writing and prompt delivery. They respect your deadline, especially one you set before the work commenced. 99Papers gives you a good customer service experience. They are passionate about the quality of your user experience on their website and the overall itinerary of each client on their platform. So, if you are looking to write your resume, they are an excellent spot to check out online. Can I pay someone to update my resume? Yes, you sure can. Nothing works by mistake. If you realize that working on your resume, either drafting from scratch or updating it, will cause massive harm to your career journey, you should seek help. And this is why these online writing services carefully curated above were not haphazardly chosen but carefully curated to bring the best experience to you. Services like Ivory Research are vast in the work of editing and proofreading. Thus, they can be of great help in updating your resume. With specialist writers on their team, they are ready to take your resume several notches higher. Similarly, companies like 99Papers are available at your fingertips to help update your resume to fit. Seeing that each resume is important to specific role applications, they are hands-on and ready to add, remove, modify, and re-write your resume to hit the spot for your application. PaperHelp and Studdit are also platforms you can check out in the updating business. They are more than keen to ramp up your resumes for you. TOP Resume Writing Services: Conclusion In the end, what matters is that your resume is well-written, whether it was written by you or by an expert. Thus, it only makes sense for you to put your best foot forward. And sometimes, by writing it yourself, the resume might be less standard than you would like it to be. Or sometimes, we are just unable to write it due to work schedules or other factors and hindrances. So, why not hire one of these best resume writing services? They will deliver you from a lot of headaches. They are very easy to access and order from. Make sure you check them out today. Contact Details Resume Builders Megan Crow contact@101resumes.com

October 08, 2022 08:49 PM Eastern Daylight Time

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Ultrahuman launches on Kickstarter ahead of US market distribution

Ultrahuman

The world's most advanced metabolic fitness platform Ultrahuman has today launched its latest wearable, the Ultrahuman Ring, on popular US product launch platform Kickstarter as the company seeks to engage the creator community and innovate with biohackers all around the world. The campaign will run until 27th October 2022. The Ultrahuman Ring is a metabolism-tracking wearable that measures movement, sleep, and the body’s energy dynamics coupled with intelligent activity or recuperating recommendations, in real-time, to balance and take control of your health. Ultrahuman Ring’s deep insights empower you with quantifying metrics related to your general health such as Movement, Heart rate, HRV, and Sleep. The Ring provides a minimal form factor with no screens or vibrations keeping you away from constant notifications. You check your details when you want to, on the app, ensuring no intrusion in your daily activities. It also comes with a power packed 5-day battery life. It is designed for enduring usage conditions and workouts. The ring’s outer surface is made of a titanium body coated with tungsten carbide which is 5 times harder than tool steel making it remarkably scratch resistant. At the same time, comfort and minimalism is at the core of the product.This is ensured by the smooth inner shell of the ring that makes it comfortable during sleep and rest scenarios. Ultrahuman Ring works standalone or in combination with the existing advanced glucose monitoring platform, Ultrahuman M1, to offer users even deeper metabolic insights and more precise actionables for optimizing your health. Ultrahuman’s core values include the approach of “No One-Size-fits-all diet” and aim at optimising health for every individual through biomarkers by quantifying the response of each user’s diet, workout, and sleep on their platform. The personalisation of this data allows a user to deep dive into their own body and make data-driven decisions for a better lifestyle. The Ring launches at $219 an exclusive super early bird price for the creator community. The retail price is estimated to be upwards of $300. As of writing this, the Ultrahuman Ring has been funded 533% over the funding goal and stands at $259831. With the help of this funding from Kickstarter, Ultrahuman is aiming to reach a global audience and make health optimisation efficient for every individual. Global shipping of the Ultrahuman Ring purchases on Kickstarter begin January 2023 onwards. Mohit Kumar, Founder and CEO, Ultrahuman commented: “We have always believed in the power of biomarkers in terms of their ability to make health optimization more efficient. With the Ultrahuman ring and a new suite of metabolic biomarkers, you can now understand not just what’s affecting your glucose metabolism but also how to act on the insights in an efficient way. For eg. You could figure how much of your glucose metabolism is affected by the lack of sleep vs the food itself. This is a phenomenal leap in the world of biomarkers and allows us to study various factors around human health in a unique and much more impactful way than ever.” Ultrahuman is a venture-backed startup that has raised $25m to date. Their investors include Alpha Wave Incubation (AWI), which is backed by DisruptAD and managed by Falcon Edge, Steadview Capital, Nexus Venture Partners, Blume Ventures and Utsav Somani’s iSeed fund, and a range of marquee founders and angel investors including Tiger Global’s Scott Schleifer. About Ultrahuman Ultrahuman is the world's most advanced metabolic fitness platform. By using glucose and other biomarkers, Ultrahuman is helping people improve their energy levels, increase focus and avoid metabolic disorders. For more information and updates on Ultrahuman, please visit ultrahuman.com or follow us on Facebook, Instagram, Twitter, LinkedIn, and YouTube. Contact Details Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://ultrahuman.com/

October 07, 2022 10:31 AM Eastern Daylight Time

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